Activated NTRK2 signals through PLCG1

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Homo sapiens
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Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream PLCgamma (PLCG1) signaling, resulting in formation of secondary messengers DAG and IP3 (Eide et al. 1996, Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999, Minichiello et al. 2002, Yamada et al. 2002).

Literature References
PubMed ID Title Journal Year
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Stucky, CL, Casagranda, F, Postigo, A, Tatche, RS, Klein, R, Davies, AM, Lewin, GR, Minichiello, L

Neuron 1998
10533983 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL

Feinstein, SC, McCarty, JH

J. Recept. Signal Transduct. Res. 1999
8627351 Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

Eide, FF, Zang, K, Vining, ER, Reichardt, LF, Wang, XY, Eide, BL

J. Neurosci. 1996
12367511 Mechanism of TrkB-mediated hippocampal long-term potentiation

Klein, R, Korte, M, Calella, AM, Medina, DL, Minichiello, L, Bonhoeffer, T

Neuron 2002
11432792 Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system

Hatanaka, H, Koizumi, S, Asada, A, Matozaki, T, Ikeuchi, T, Suzuki, K, Mizutani, M, Yamada, M

J. Biochem. 2001
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
Event Information
Orthologous Events
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