Reactome | Activated NTRK2 signals through PLCG1

Activated NTRK2 signals through PLCG1

Stable Identifier

R-HSA-9026527

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream PLCgamma (PLCG1) signaling, resulting in formation of secondary messengers DAG and IP3 (Eide et al. 1996, Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999, Minichiello et al. 2002, Yamada et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9728915	Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses Stucky, CL, Casagranda, F, Postigo, A, Tatche, RS, Klein, R, Davies, AM, Lewin, GR, Minichiello, L	Neuron	1998
10533983	The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL Feinstein, SC, McCarty, JH	J. Recept. Signal Transduct. Res.	1999
8627351	Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling Eide, FF, Zang, K, Vining, ER, Reichardt, LF, Wang, XY, Eide, BL	J. Neurosci.	1996
12367511	Mechanism of TrkB-mediated hippocampal long-term potentiation Klein, R, Korte, M, Calella, AM, Medina, DL, Minichiello, L, Bonhoeffer, T	Neuron	2002
11432792	Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system Hatanaka, H, Koizumi, S, Asada, A, Matozaki, T, Ikeuchi, T, Suzuki, K, Mizutani, M, Yamada, M	J. Biochem.	2001
10486198	Early BDNF, NT-3, and NT-4 signaling events Yuen, EC, Mobley, WC	Exp. Neurol.	1999