Activated PCLG1 dissociates from NTRK2

Stable Identifier
R-HSA-9026894
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Activated PCLG1 dissociates from NTRK2
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Based on the accepted model of PLCgamma1 (PLCG1) signaling, although this has not been tested in the context of the NTRK2 (TRKB) receptor-mediated activation of PLCG1, phosphorylated, active, PLCG1 dissociates from the receptor tyrosine kinase and catalyzes formation of DAG and IP3 second messengers (Carpener and Ji 1999).
Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Ji, Q, Carpenter, G

Exp Cell Res 1999
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Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-10-24)
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