Based on the accepted model of PLCgamma1 (PLCG1) signaling, although this has not been tested in the context of the NTRK2 (TRKB) receptor-mediated activation of PLCG1, phosphorylated, active, PLCG1 dissociates from the receptor tyrosine kinase and catalyzes formation of DAG and IP3 second messengers (Carpener and Ji 1999).
Ji, Q, Carpenter, G
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