Activated PCLG1 dissociates from NTRK2

Stable Identifier
R-HSA-9026894
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated PCLG1 dissociates from NTRK2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on the accepted model of PLCgamma1 (PLCG1) signaling, although this has not been tested in the context of the NTRK2 (TRKB) receptor-mediated activation of PLCG1, phosphorylated, active, PLCG1 dissociates from the receptor tyrosine kinase and catalyzes formation of DAG and IP3 second messengers (Carpener and Ji 1999).

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
Participants
Input
Output
Participates
as an event of
Orthologous Events
Activated PCLG1 dissociates from NTRK2 (Canis familiaris)
Activated PCLG1 dissociates from NTRK2 (Danio rerio)
Activated PCLG1 dissociates from NTRK2 (Gallus gallus)
Activated PCLG1 dissociates from NTRK2 (Mus musculus)
Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)
Activated PCLG1 dissociates from NTRK2 (Sus scrofa)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-10-24)
Cite Us!