NTRK2 phosphorylates SHC1

Stable Identifier
R-HSA-9026890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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NTRK2 phosphorylates SHC1
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Activated NTRK2 (TRKB) phosphorylates SHC1-2 (SHC1 p52) isoform at tyrosine residue Y317. This tyrosine residue corresponds to Y272 of SHC1-3 (SHC1 p46) isoform (Chan et al. 2011).

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Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane]

Physical Entity
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Activated Ntrk2 phosphorylates Shc1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-10-24)
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