NTRK2 phosphorylates SHC1

Stable Identifier
R-HSA-9026890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NTRK2 phosphorylates SHC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated NTRK2 (TRKB) phosphorylates SHC1-2 (SHC1 p52) isoform at tyrosine residue Y317. This tyrosine residue corresponds to Y272 of SHC1-3 (SHC1 p46) isoform (Chan et al. 2011).

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane]
Physical Entity
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Activated Ntrk2 phosphorylates Shc1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-10-24)