BDNF-bound NTRK2 dimers trans-autophosphorylate

Stable Identifier
R-HSA-9026464
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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BDNF-induced dimerization of the receptor tyrosine kinase NTRK2 (TRKB) leads to trans-autophosphorylation of NTRK2 on five evolutionarily conserved tyrosine residues in the cytoplasmic tail of NTRK2: Y516, Y702, Y706, Y707 and Y817. Phosphorylation at Y516, Y702, Y706, Y707 and Y817 was demonstrated by using a recombinant human BDNF and a recombinant rat Ntrk2. Tyrosine residues Y516, Y702, Y706, Y707 and Y817 of full-length human NTRK2 correspond to Y484, Y670, Y674, Y675 and Y785 of mature rat Ntrk2 (Y515, Y701, Y705, Y706 and Y816 of full-length rat Ntrk2), respectively (Guiton et al. 1994, McCarty and Feinstein 1999). Human NTRK2 residue Y516 corresponds to mouse Ntrk2 residue Y515, which was also shown to be phosphorylated in response to BDNF stimulation (Minichiello et al. 1998).

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Catalyst Activity
Title
protein tyrosine kinase activity of BDNF:NTRK2 homodimer [plasma membrane]
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