Estrogen-dependent expression of TFF1 depends on the recruitment of histone acetyltransferases such as KAT5, EP300, CITED1 and KAT2B, as well as coactivators such as NCOA1 and NCOA3 (Métivier et al, 2003; reviewed in Arnal et al, 2017). ChIP analysis suggests that NCOA1 and NCOA3 do not co-occupy the TFF1 promoter, but may be differentially recruited under different conditions (Métivier et al, 2003). Note that the acetyltransferase activity of these HATs is not depicted in this diagram.
Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M
Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR
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