Histone acetyltransferases are recruited to the TFF1 gene

Stable Identifier
Reaction [binding]
Homo sapiens
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Estrogen-dependent expression of TFF1 depends on the recruitment of histone acetyltransferases such as KAT5, EP300, CITED1 and KAT2B, as well as coactivators such as NCOA1 and NCOA3 (Métivier et al, 2003; reviewed in Arnal et al, 2017). ChIP analysis suggests that NCOA1 and NCOA3 do not co-occupy the TFF1 promoter, but may be differentially recruited under different conditions (Métivier et al, 2003). Note that the acetyltransferase activity of these HATs is not depicted in this diagram.

Literature References
PubMed ID Title Journal Year
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M

Physiol. Rev. 2017
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR

Cell 2003
Orthologous Events
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