FKBP5 gene expression is inhibited by MECP2

Stable Identifier
R-HSA-9022728
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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FKBP5 gene expression is inhibited by MECP2
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Based on studies in mice, MECP2 directly inhibits transcription of the FKBP5 gene, encoding peptidyl-prolyl cis-trans isomerase involved in trafficking of glucocorticoid receptors. Fkbp5 level is increased in Mecp2 null mice (Nuber et al. 2005, Urdinguio et al. 2008).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:FKBP5 gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Inferred From
Fkbp5 gene expression is inhibited by Mecp2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-25)
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