Fkbp5 gene expression is inhibited by Mecp2

Stable Identifier
R-MMU-9022717
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Fkbp5 gene expression is inhibited by Mecp2
Mouse Mecp2 directly inhibits transcription of the mouse Fkbp5 gene, encoding peptidyl-prolyl cis-trans isomerase involved in trafficking of glucocorticoid receptors. Fkbp5 level is increased in Mecp2 null mice (Nuber et al. 2005, Urdinguio et al. 2008).
Literature References
PubMed ID Title Journal Year
16002417 Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome

Guy, J, Nuber, UA, Roloff, TC, Bird, A, Lipkowitz, B, Selfridge, J, Ropers, HH, Holmes, MC, Steinhoff, C, Schulz, R, Kriaucionis, S

Hum. Mol. Genet. 2005
18989361 Mecp2-null mice provide new neuronal targets for Rett syndrome

Diaz-Uriarte, R, Fernandez, AF, Lopez-Serra, L, Lopez-Nieva, P, Urdinguio, RG, Esteller, M, Alaminos, M

PLoS ONE 2008
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Mecp2:Fkbp5 gene [nucleoplasm] (Mus musculus)
Active Unit
Mecp2 [nucleoplasm]
Orthologous Events
FKBP5 gene expression is inhibited by MECP2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-25)
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