Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ALOX15 [cytosol]
Stable Identifier
R-HSA-2142838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Arachidonate 15-lipoxygenase, LOX15_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of HSPA8, ALOX15 (Homo sapiens)
HSPA8, ALOX15 [cytosol] (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
ALOX15 oxidises DHA to 17(S)-Hp-DHA (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Biosynthesis of protectins (Homo sapiens)
ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
ALOX15 oxidises 17(S)-Hp-DHA to PDX (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Biosynthesis of DPA-derived SPMs (Homo sapiens)
Biosynthesis of DPAn-3 SPMs (Homo sapiens)
Biosynthesis of DPAn-3-derived protectins and resolvins (Homo sapiens)
ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Biosynthesis of DPAn-6 SPMs (Homo sapiens)
ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Biosynthesis of EPA-derived SPMs (Homo sapiens)
Biosynthesis of E-series 18(R)-resolvins (Homo sapiens)
ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Biosynthesis of E-series 18(S)-resolvins (Homo sapiens)
ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)
ALOX12/15 [cytosol] (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Homo sapiens)
ALOX15/15B [cytosol] (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)
ALOX15:Fe2+ [cytosol] (Homo sapiens)
ALOX15 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16050 ALOX15
Gene Names
ALOX15, LOG15
Chain
initiator methionine:1, chain:2-662
Reference Genes
BioGPS Gene:246 ALOX15
COSMIC (genes):ALOX15 ALOX15
CTD Gene:246 ALOX15
dbSNP Gene:246 ALOX15
ENSEMBL:ENSG00000161905 ALOX15
ENSEMBL:ENSG00000161905.13 ALOX15
HGNC:433 ALOX15
KEGG Gene (Homo sapiens):246 ALOX15
Monarch:246 ALOX15
NCBI Gene:246 ALOX15
OMIM:152392 ALOX15
UCSC:P16050 ALOX15
Reference Transcript
RefSeq:NM_001140.3 ALOX15
Other Identifiers
11734503_x_at
11750344_a_at
11750808_a_at
16840066
207328_3p_at
207328_PM_at
207328_at
246
3179528
3179529
34636_at
3708031
3708039
3708049
3708055
3708057
3742213
3742214
3742215
3742216
3742217
3742218
3742219
3742221
3742222
3742223
3742225
3742226
3742227
3742228
3742229
3742230
3742231
8011680
A_23_P55373
GE80985
GO:0001503
GO:0001676
GO:0002376
GO:0002820
GO:0003824
GO:0004052
GO:0005506
GO:0005515
GO:0005546
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0006629
GO:0006631
GO:0006646
GO:0006690
GO:0006954
GO:0007010
GO:0007155
GO:0008289
GO:0009898
GO:0010811
GO:0016020
GO:0016165
GO:0016192
GO:0016491
GO:0016702
GO:0019369
GO:0019372
GO:0019395
GO:0023052
GO:0030282
GO:0030838
GO:0034440
GO:0034976
GO:0035358
GO:0035963
GO:0042060
GO:0042759
GO:0043226
GO:0043277
GO:0043651
GO:0046872
GO:0048856
GO:0050473
GO:0050727
GO:0051122
GO:0051213
GO:0061024
GO:0065003
GO:0070374
GO:0071277
GO:1901074
GO:2001303
HMNXSV003000410
ILMN_1676042
ILMN_1729320
ILMN_1783443
ILMN_2403534
M23892_s_at
PH_hs_0028952
TC17001027.hg
g4502054_3p_x_at
Participates
as a member of
HSPA8, ALOX15 [cytosol] (Homo sapiens)
as a component of
ALOX15:Fe2+ [cytosol] (Homo sapiens)
Inferred To
lipA [cytosol]
(Dictyostelium discoideum)
Homologues of ALOX15 [cytosol]
(Dictyostelium discoideum)
ALOX15 [cytosol]
(Bos taurus)
ALOX15 [cytosol]
(Canis familiaris)
ALOX15 [cytosol]
(Danio rerio)
ALOX15 [cytosol]
(Dictyostelium discoideum)
ALOX15 [cytosol]
(Mus musculus)
ALOX15 [cytosol]
(Rattus norvegicus)
ALOX15 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001131.3
ZINC - World Drugs
LOX15_HUMAN
Guide to Pharmacology - Targets
1388
OpenTargets
ENSG00000161905
ZINC - Substances
LOX15_HUMAN
ZINC target
P16050
ZINC - Biogenic
LOX15_HUMAN
PRO
P16050
ZINC - Metabolites
LOX15_HUMAN
GeneCards
P16050
HPA
ENSG00000161905-ALOX15
Ensembl
ENSG00000161905
,
ENST00000574640
,
ENST00000293761
,
ENSP00000458832
,
ENSP00000293761
,
ENSP00000460483
,
ENST00000570836
Pharos - Targets
P16050
ZINC - Predictions - Purchasable
LOX15_HUMAN
HMDB Protein
HMDBP00977
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30086 PEBP1
1
PEBP1 [cytosol]
(R-HSA-61487)
0.499
3
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text