RHOT1 GEFs activate RHOT1

Stable Identifier
R-HSA-9018817
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane, cytosol
ReviewStatus
5/5
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RHOT1 GEFs activate RHOT1
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Based on studies in Drosophila, RAP1GDS1, an orthologue of Drosophila Vimar, is a mitochondrial outer membrane-bound atypical guanine nucleotide exchange factor (GEF) that activates mitochondria-associated atypical RHO GTPase RHOT1, an orthologue of Drosophila Miro, by catalyzing GDP to GTP exchange, resulting in formation of the active RHOT1:GTP complex (Ding et al. 2016).
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Catalyst Activity

guanyl-nucleotide exchange factor activity of RAP1GDS1 [mitochondrial outer membrane]

Physical Entity
RAP1GDS1 [mitochondrial outer membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Inferred From
Vimar activates Miro (Drosophila melanogaster)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Schrader, M  (2021-02-09)
Castro, IG  (2021-02-09)
Created
Orlic-Milacic, M  (2017-09-05)
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