RHOV binds GTP

Stable Identifier
R-HSA-9018798
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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RHOV can bind both GTP and GDP, and interacts with effectors when in active, GTP-bound state (Aronheim et al. 1998, Shepelev and Korobko 2012). Based on the sequence similarity between RHOV and RHOU, it is assumed that RHOV possesses high intrinsic guanine nucleotide exchange activity, but this has not been experimentally confirmed.

Literature References
PubMed ID Title Journal Year
22339630 Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV

Shepelev, MV, Korobko, IV

Biochemistry Mosc. 2012
9778532 Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

Aronheim, A, Broder, YC, Cohen, A, Fritsch, A, Belisle, B, Abo, A

Curr. Biol. 1998
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