Reactome | RHOV binds GTP

RHOV binds GTP

Stable Identifier

R-HSA-9018798

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOV can bind both GTP and GDP, and interacts with effectors when in active, GTP-bound state (Aronheim et al. 1998, Shepelev and Korobko 2012). It should be noted that the binding of both GTP and GDP has never been experimentally confirmed for RHOV in a proper biochemical way. All the assumptions for GTP and GDP binding are inferred from the use of G40V/Q89L “active, GTPase deficient” and S45N “inactive” mutants. Based on the sequence similarity between RHOV and RHOU, it is assumed that RHOV possesses high intrinsic guanine nucleotide exchange activity, but this has not been experimentally confirmed.

Literature References

PubMed ID	Title	Journal	Year
9778532	Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton Aronheim, A, Broder, YC, Cohen, A, Fritsch, A, Belisle, B, Abo, A	Curr. Biol.	1998
22339630	Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV Shepelev, MV, Korobko, IV	Biochemistry Mosc.	2012