RHOV GTPase cycle

Stable Identifier
R-HSA-9013424
Type
Pathway
Species
Homo sapiens
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RHOV (also known as Chp) is an atypical RHO GTPase that is thought to be constitutively active due to its high intrinsic guanine nucleotide exchange activity. No guanine nucleotide exchange factors (GEFs) nor GTPase activator proteins (GAPs) that act on RHOV have been identified. RHOV is expressed at very low levels. The expression of RHOV is detected during embryonic development in fish (Tay et al. 2010), frog (Guémar et al. 2007) and chicken (Notarnicola et al. 2008). RHOV is involved in neural crest formation, where its expression is induced downstream of WNT signaling. RHOV is thought to regulate cell adhesion, as its zebrafish orthologue is required for proper localization of E-cadherin and beta-catenin at adherens junctions. RHOV activates JNK and induces apoptosis in rat pheochromocytoma cell line PC12 (Shepelev et al 2011) and in macrophages (Song et al. 2015).

RHOV gene overexpression is a molecular marker of human lung adenocarcinoma (Shepelev and Korobko 2013, Shukla et al. 2017, Ma et al. 2020, Zhang et al. 2020), where RHOV is likely to act as an oncogene (Chen et al. 2021).

For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020.

Literature References
PubMed ID Title Journal Year
26555387 Atypical RhoV and RhoU GTPases control development of the neural crest

Fort, P, Faure, S

Small GTPases 2015
17761159 The small GTPase RhoV is an essential regulator of neural crest induction in Xenopus

Fort, P, de Santa Barbara, P, Faure, S, Guémar, L, Vignal, E, Maurel, B

Dev Biol 2007
29189096 Regulation and functions of RhoU and RhoV

Ridley, AJ, Hodge, RG

Small GTPases 2020
24388711 The RHOV gene is overexpressed in human non-small cell lung cancer

Korobko, IV, Shepelev, MV

Cancer Genet 2013
25354898 RhoV mediates apoptosis of RAW264.7 macrophages caused by osteoclast differentiation

Wang, Q, Gao, Q, Yuan, Y, Liu, X, Zhang, J, Song, R, Liu, Z, Cheng, L, Hu, D, Zhu, J, Gu, J, Wang, D

Mol Med Rep 2015
18351666 Dynamic expression patterns of RhoV/Chp and RhoU/Wrch during chicken embryonic development

Fort, P, de Santa Barbara, P, Faure, S, Le Guen, L, Notarnicola, C

Dev Dyn 2008
31956375 Identification of a Sixteen-gene Prognostic Biomarker for Lung Adenocarcinoma Using a Machine Learning Method

Geng, Y, Meng, F, Yan, G, Ma, B, Song, F

J Cancer 2020
27707839 Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma

Chen, G, Shukla, S, Beer, DG, Dhanasekaran, SM, Malik, R, Cao, X, Chinnaiyan, AM, Jiang, H, Evans, JR, Feng, FY

J Natl Cancer Inst 2017
33195688 Development and Validation of a Seven-Gene Signature for Predicting the Prognosis of Lung Adenocarcinoma

Lv, X, Fang, Z, Liu, J, Zhang, X, Gao, X, Zhang, M, Xu, Y, Zhang, Y, Chen, W

Biomed Res Int 2020
33767988 Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma

Zhang, Y, Xia, H, Yao, C, Zhou, Y, Chen, H, Peng, W, Xia, R, Wang, Y, Zhou, G, Xu, H, Jiang, L

Front Oncol 2021
21686277 Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation

Korobko, IV, Shepelev, MV, Chernoff, J

Small GTPases 2011
20405038 A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly

Ng, YW, Tay, HG, Manser, E

PLoS One 2010
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