RHOV GTPase cycle

Stable Identifier
R-HSA-9013424
Type
Pathway
Species
Homo sapiens
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RHOV (also known as Chp) is an atypical RHO GTPase that is thought to be constitutively active due to its high intrinsic guanine nucleotide exchange activity. No guanine nucleotide exchange factors (GEFs) nor GTPase activator proteins (GAPs) that act on RHOV have been identified. RHOV is expressed at very low levels. RHOV is involved in neural crest formation, where its expression is induced downstream of WNT signaling. RHOV is thought to regulate cell adhesion, as its zebrafish orthologue is required for proper localization of E-cadherin and beta-catenin at adherens junctions.
For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020.

Literature References
PubMed ID Title Journal Year
29189096 Regulation and functions of RhoU and RhoV

Hodge, RG, Ridley, AJ

Small GTPases 2020
26555387 Atypical RhoV and RhoU GTPases control development of the neural crest

Faure, S, Fort, P

Small GTPases 2015
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