RHOU GTPase cycle

Stable Identifier
R-HSA-9013420
Type
Pathway
Species
Homo sapiens
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RHO GTPase RHOU (Wrch-1) possesses a high intrinsic guanine nucleotide exchange activity and is constitutively present in the active GTP-bound state in the absence of guanine nucleotide exchange factors (GEFs) (Shutes et al. 2004, Saras et al. 2004). RHOU does not possess a GTPase activity (Saras et al. 2004). RHOU has been reported to interact with some GTPase activator proteins (GAPs) (Bagci et al. 2020), which may serve as effectors that enable cross-talk with other RHO GTPases.
For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020.

Literature References
PubMed ID Title Journal Year
29189096 Regulation and functions of RhoU and RhoV

Hodge, RG, Ridley, AJ

Small GTPases 2020
26555387 Atypical RhoV and RhoU GTPases control development of the neural crest

Faure, S, Fort, P

Small GTPases 2015
15556869 Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

Shutes, A, Berzat, AC, Cox, AD, Der, CJ

Curr. Biol. 2004
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