Reactome | RHOU GTPase cycle

RHOU GTPase cycle

Stable Identifier

R-HSA-9013420

DOI

10.3180/R-HSA-9013420.2

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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RHO GTPase RHOU (Wrch-1) possesses a high intrinsic guanine nucleotide exchange activity and is constitutively present in the active GTP-bound state in the absence of guanine nucleotide exchange factors (GEFs) (Shutes et al. 2004, Saras et al. 2004). RHOU does not possess a GTPase activity (Saras et al. 2004). RHOU has been reported to interact with some GTPase activator proteins (GAPs) (Bagci et al. 2020), which may serve as effectors that enable cross-talk with other RHO GTPases. RHOU was shown to regulate cytoskeletal dynamics, cell migration and adhesion. RHOU is expressed during embryonic development and regulates cardiac (Dickover et al. 2014) and intestinal (Slaymi et al. 2019) development. RHOU activates JNK and AKT signaling during cell migration (Chuang et al. 2007).
For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020.

Literature References

PubMed ID	Title	Journal	Year
26555387	Atypical RhoV and RhoU GTPases control development of the neural crest Fort, P, Faure, S	Small GTPases	2015
30834544	The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium Fort, P, Raynaud, P, Roux, P, Cres, G, Vignal, E, Blangy, A, Slaymi, C	Biol Cell	2019
17504809	The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration Valster, A, Chuang, YY, Coniglio, SJ, Symons, M, Backer, JM	J Cell Sci	2007
29189096	Regulation and functions of RhoU and RhoV Ridley, AJ, Hodge, RG	Small GTPases	2020
15556869	Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase Der, CJ, Shutes, A, Cox, AD, Berzat, AC	Curr. Biol.	2004
18086875	The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics Ruusala, A, Aspenström, P	Mol Cell Biol	2008
24607366	The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis Hegarty, JM, Tedeschi, N, Lopez, D, Zhang, R, Yang, H, Chi, NC, Ly, K, Dickover, M, Hsiai, TK	Dev Biol	2014