Estrogen-responsive TFF3 gene expression

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Reaction [omitted]
Homo sapiens
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Estrogen-dependent TFF3 expression is promoted by the formation of FOXA1- and GATA3-dependent chromatin loops. Interaction of ligand-bound ESR1 with the enhancer promotes recruitment of EP300 and other chromatin modifying enzymes, and stimulates the deposition of active chromatin marks like H3K4 methylation and H3K27 acteylation (Laganière et al, 2005; Theodorou et al, 2013; reviewed in Zaret and Carroll, 2011)

Literature References
PubMed ID Title Journal Year
23172872 GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

Theodorou, V, Stark, R, Menon, S, Carroll, JS

Genome Res. 2013
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
23192763 Cooperating transcription factors mediate the function of estrogen receptor

Fiorito, E, Katika, MR, Hurtado, A

Chromosoma 2013
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