Estrogen-responsive CXXC5 gene expresion

Stable Identifier
R-HSA-9018334
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Estrogen-responsive CXXC5 gene expresion
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CXXC5 expression is estrogen-responsive and depends on the interaction of ligand-bound ESR1 with an ERE at -242 of the promoter (Nott et al, 2009; Yaşar et al, 2016). CXXC5 is a transcription factor that plays roles in cellular proliferation and differentiation (Andersson et al, 2009; Kim et al, 2010; Aras et al, 2013; Li et al, 2014; Kim et al, 2016; Kim et al, 2015; Lee et al, 2015; Wang et al, 2013) KANK1 is an additional positive regulator of CXX5 expression. KANK1 is a regulator of cytoskeleton rearrangements that has been identified as a putative tumor suppressor gene that promotes CXXC5-dependent apoptosis (Wang et al, 2006; Kakinuma et al, 2008; Roy et al, 2009; Li et al, 2011; Cui et al, 2017). KANK1 mutations have been identified in renal cell carinomas, malignant peripheral nerve sheath tumors (MPNST), and cancers of the prostate, pancreas, uterus and stomach (Sarkar et al, 2002; Medves et al, 2010; Cui et al, 2017). Re-expression of KANK1 in depleted MPNST cell lines and mouse xenograph models decreases cell growth rates, increases CXXC5 protein levels and increases CXXC5-mediated apoptosis (Cui et al, 2017).
Literature References
PubMed ID Title Journal Year
20220130 A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway

Rivera, MN, Lee, SB, Perantoni, AO, Bollig, F, Whye, NJ, Bell, DW, Park, JY, Yoon, SK, Kitagaki, J, Englert, C, Wu, YP, Malik, K, Hur, W, Kim, MS, Kim, HS

J. Biol. Chem. 2010
26462610 CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation

Lee, Y, Min, do S, Hong, J, Choi, KY, Kim, MY, Lee, H, Kim, D, Roth, J, Kim, DG, Cheong, E, Kim, HY

Glia 2016
19321454 Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations

Huang, Y, Welshons, WV, Fluharty, BR, Yeh, S, Qiu, X, Muyan, M, Li, X, Nott, SL

J. Biol. Chem. 2009
26056233 The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

Min, do S, Kim, H, Choi, KY, Roh, MR, Nam, KA, Kim, MY, Chung, KY, Lee, SH, Lee, YM, Kim, HY

J. Exp. Med. 2015
19001364 CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells

Cascante, A, Hermanson, O, Södersten, E, Bryja, V, Fritz, N, Sacchetti, P, Cervenka, I, Duckworth, JK, Andersson, T

J. Biol. Chem. 2009
27886276 Estradiol-Estrogen Receptor α Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway

Muyan, M, Ayaz, G, Yaşar, P

Sci Rep 2016
23906331 CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis

Yuan, W, Li, Y, Ocorr, K, Liao, P, Jiang, Z, Mo, X, Fan, X, Wang, X, Wan, Y, Wu, X, Wang, Y, Ye, X, Deng, Y

Curr. Mol. Med. 2013
25633194 CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation

Yoon, JY, Yun, JH, No, KT, Cho, KW, Rhee, YM, Lee, H, Choi, J, Lee, W, Choi, KY, Kim, HY, Min, D, Jung, HS, Heo, JN, Lim, HJ, Lee, SH

Cell Death Differ. 2015
23303788 Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

Finley, R, Grossman, LI, Aras, S, Hüttemann, M, Pak, O, Sommer, N, Weissmann, N

Nucleic Acids Res. 2013
25433557 CXXC5 regulates differentiation of C2C12 myoblasts into myocytes

Jiang, Z, Mo, X, Liu, X, Ye, X, Wang, X, Chen, T, Wang, Y, Li, Y, Fan, X, Wu, X, Deng, Y, Wan, Y, Yuan, W, Peng, X, Li, G

J. Muscle Res. Cell. Motil. 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CXXC5 gene:ESR1:ESTG [nucleoplasm] (Homo sapiens)
Regulator
KANK1 [nucleoplasm] (Homo sapiens)
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-08-30)
Cite Us!