Estrogen-responsive CXXC5 gene expresion

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Reaction [omitted]
Homo sapiens
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CXXC5 expression is estrogen-responsive and depends on the interaction of ligand-bound ESR1 with an ERE at -242 of the promoter (Nott et al, 2009; Yaşar et al, 2016). CXXC5 is a transcription factor that plays roles in cellular proliferation and differentiation (Andersson et al, 2009; Kim et al, 2010; Aras et al, 2013; Li et al, 2014; Kim et al, 2016; Kim et al, 2015; Lee et al, 2015; Wang et al, 2013)

Literature References
PubMed ID Title Journal Year
26462610 CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation

Kim, MY, Kim, HY, Hong, J, Kim, D, Lee, H, Cheong, E, Lee, Y, Roth, J, Kim, DG, Min, do S, Choi, KY

Glia 2016
20220130 A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway

Kim, MS, Yoon, SK, Bollig, F, Kitagaki, J, Hur, W, Whye, NJ, Wu, YP, Rivera, MN, Park, JY, Kim, HS, Malik, K, Bell, DW, Englert, C, Perantoni, AO, Lee, SB

J. Biol. Chem. 2010
19321454 Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations

Nott, SL, Huang, Y, Li, X, Fluharty, BR, Qiu, X, Welshons, WV, Yeh, S, Muyan, M

J. Biol. Chem. 2009
26056233 The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

Lee, SH, Kim, MY, Kim, HY, Lee, YM, Kim, H, Nam, KA, Roh, MR, Min, do S, Chung, KY, Choi, KY

J. Exp. Med. 2015
19001364 CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells

Andersson, T, Södersten, E, Duckworth, JK, Cascante, A, Fritz, N, Sacchetti, P, Cervenka, I, Bryja, V, Hermanson, O

J. Biol. Chem. 2009
27886276 Estradiol-Estrogen Receptor α Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway

Yaşar, P, Ayaz, G, Muyan, M

Sci Rep 2016
23906331 CXXC5 Associates with Smads to Mediate TNF-α Induced Apoptosis

Wang, X, Liao, P, Fan, X, Wan, Y, Wang, Y, Li, Y, Jiang, Z, Ye, X, Mo, X, Ocorr, K, Deng, Y, Wu, X, Yuan, W

Curr. Mol. Med. 2013
25633194 CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation

Kim, HY, Yoon, JY, Yun, JH, Cho, KW, Lee, SH, Rhee, YM, Jung, HS, Lim, HJ, Lee, H, Choi, J, Heo, JN, Lee, W, No, KT, Min, D, Choi, KY

Cell Death Differ. 2015
23303788 Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2

Aras, S, Pak, O, Sommer, N, Finley, R, Hüttemann, M, Weissmann, N, Grossman, LI

Nucleic Acids Res. 2013
25433557 CXXC5 regulates differentiation of C2C12 myoblasts into myocytes

Li, G, Ye, X, Peng, X, Deng, Y, Yuan, W, Li, Y, Mo, X, Wang, X, Wan, Y, Liu, X, Chen, T, Jiang, Z, Fan, X, Wu, X, Wang, Y

J. Muscle Res. Cell. Motil. 2014
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