Crh gene expression is repressed by Mecp2

Stable Identifier
R-MMU-9017984
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Crh gene expression is repressed by Mecp2
Mouse Mecp2 represses transcription from the Crh gene promoter, encoding corticotropin-release hormone (corticoliberin). Crh is overexpressed in Mecp2 knockout mice, a mouse model of Rett syndrome, which results in enhanced anxiety and stress-induced corticosterone release (McGill et al. 2006). Surprisingly, Crh is also overexpressed in the mouse model of the Mecp2 duplication syndrome (Samaco et al. 2012).
Literature References
PubMed ID Title Journal Year
22231481 Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

Mandel-Brehm, C, Samaco, RC, Zoghbi, HY, McGill, BE, Shaw, CA, McGraw, CM

Nat. Genet. 2012
17108082 Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

Carson, JP, Bundle, SF, Zoghbi, HY, McGill, BE, Yaylaoglu, MB, Thaller, C

Proc. Natl. Acad. Sci. U.S.A. 2006
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Mecp2:Crh gene [nucleoplasm] (Mus musculus)
Active Unit
Mecp2 [nucleoplasm]
Orthologous Events
CRH gene expression is repressed by MECP2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-08-29)
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