Reactome | RHOD GTPase cycle

RHOD GTPase cycle

Stable Identifier

R-HSA-9013405

DOI

10.3180/R-HSA-9013405.2

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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This pathway catalogues RHOD GTPase activator proteins (GAPs) and RHOD effectors. RHOD possesses GTPase activity and is therefore grouped with classical RHO GTPases but it is atypical in the sense that no known guanine nucleotide exchange factors (GEFs) and no GDP dissociation inhibitors (GDIs) (Blom et al. 2017) are involved in the regulation of RHOD activity. RHOD possesses an elevated intrinsic guanine nucleotide exchange activity and auto-activates (Jaiswal, Fansa et al. 2013). RHOD regulates cytoskeletal dynamics and intracellular transport of vesicles (Gad and Aspenstrom 2010; Aspenstrom et al. 2014), especially actin-dependent movement of endosomes (Gasman et al. 2003, reviewed in Randazzo 2003).

Literature References

PubMed ID	Title	Journal	Year
24622787	Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking Aspenström, P	Biol. Chem.	2014
12636908	RhoD, Src, and hDia2C in endosome motility Randazzo, PA	Dev. Cell	2003
19818399	Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking Gad, AK, Aspenström, P	Cell. Signal.	2010
28196728	The atypical Rho GTPase RhoD is a regulator of actin cytoskeleton dynamics and directed cell migration Blom, M, Reis, K, Heldin, J, Kreuger, J, Aspenström, P	Exp. Cell Res.	2017
23096567	New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm Jaiswal, M, Fansa, EK, Dvorsky, R, Ahmadian, MR	Biol. Chem.	2013
12577064	RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase Gasman, S, Kalaidzidis, Y, Zerial, M	Nat. Cell Biol.	2003