VDAC1 transports PYR from cytosol to mitochondrial intermembrane space

Stable Identifier
R-HSA-9012374
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Similar to other ions and metabolites, pyruvate (PYR) probably crosses the outer mitochondrial membrane through the relatively non-specific, voltage-dependent anion-selective channel protein 1 (VDAC1) (McCommis & Finck 2015). Humans with defective VDAC1 show impaired PYR oxidation and ATP production (Huizing et al. 1996).

Literature References
PubMed ID Title Journal Year
8726225 Deficiency of the voltage-dependent anion channel: a novel cause of mitochondriopathy

Huizing, M, Ruitenbeek, W, Thinnes, FP, DePinto, V, Wendel, U, Trijbels, FJ, Smit, LM, ter Laak, HJ, van den Heuvel, LP

Pediatr. Res. 1996
Participants
Participates
Catalyst Activity

voltage-gated anion channel activity of VDAC1 [mitochondrial outer membrane]

Orthologous Events
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