VDAC1 transports PYR from cytosol to mitochondrial intermembrane space

Stable Identifier
R-HSA-9012374
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial intermembrane space, mitochondrial outer membrane
ReviewStatus
5/5
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VDAC1 transports PYR from cytosol to mitochondrial intermembrane space
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Similar to other ions and metabolites, pyruvate (PYR) probably crosses the outer mitochondrial membrane through the relatively non-specific, voltage-dependent anion-selective channel protein 1 (VDAC1) (McCommis & Finck 2015). Humans with defective VDAC1 show impaired PYR oxidation and ATP production (Huizing et al. 1996).

Literature References
PubMed ID Title Journal Year
8726225 Deficiency of the voltage-dependent anion channel: a novel cause of mitochondriopathy

Thinnes, FP, ter Laak, HJ, van den Heuvel, LP, Trijbels, FJ, Smit, LM, Wendel, U, Huizing, M, DePinto, V, Ruitenbeek, W

Pediatr. Res. 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

voltage-gated anion channel activity of VDAC1 [mitochondrial outer membrane]

Physical Entity
VDAC1 [mitochondrial outer membrane] (Homo sapiens)
Activity
voltage-gated anion channel activity (GO:0008308)
Orthologous Events
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Bos taurus)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Caenorhabditis elegans)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Canis familiaris)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Danio rerio)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Dictyostelium discoideum)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Drosophila melanogaster)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Gallus gallus)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Mus musculus)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Plasmodium falciparum)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Rattus norvegicus)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Saccharomyces cerevisiae)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Schizosaccharomyces pombe)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Sus scrofa)
VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Xenopus tropicalis)
Authored
Jassal, B  (2017-07-13)
Reviewed
Rutter, J  (2018-04-03)
Created
Jassal, B  (2017-07-13)
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