Estrogen-responsive KPNA2 gene transcription

Stable Identifier
R-HSA-9012209
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Estrogen-responsive KPNA2 gene transcription
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KPNA2 is a member of the karyopherin alpha family that recognized cargo proteins at the nuclear pore to facilitate their nucleocytoplasmic transport (reviewed in Christiansen and Dyrskjot, 2013). KPNA2 is highly expressed in many cancers and has been shown to be stimulated by estrogen (Tan et al, 2014). KPNA2 expression is negatively regulated by direct binding of mIR-26A and mIR-26B to the 3'UTR (Tan et al, 2014).
Literature References
PubMed ID Title Journal Year
24735615 Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2

Tan, S, Ding, K, Li, R, Zhang, W, Li, G, Kong, X, Qian, P, Lobie, PE, Zhu, T

Breast Cancer Res. 2014
23268335 The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

Christiansen, A, Dyrskjøt, L

Cancer Lett. 2013
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This event is regulated
Positively by
Regulator
ESTG [nucleoplasm]
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-11)
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