miR-26A and B bind to the 3'UTR of the KPNA2 mRNA

Stable Identifier
R-HSA-9012208
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
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Translation of KPNA2 mRNA is negatively regulated by mIR-26A and B, which bind directly to the 3'UTR. mIR-26A and B are both downregulated in the presence of estrogen in a manner that depends on estrogen-stimulated MYC gene expression. Of the nine identified estrogen-responsive, mIR-26 regulated genes, GREB1, CHD1 and KPNA2 are the only three that contribute to the proliferative response to estrogen (Tan et al, 2014). KPNA2 expression has also been demonstrated to be regulated by mIR-26 binding in ovarian cancer (Lin et al 2015).
Literature References
PubMed ID Title Journal Year
24735615 Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2

Tan, S, Ding, K, Li, R, Zhang, W, Li, G, Kong, X, Qian, P, Lobie, PE, Zhu, T

Breast Cancer Res. 2014
26204489 MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4

Lin, J, Zhang, L, Huang, H, Huang, Y, Huang, L, Wang, J, Huang, S, He, L, Zhou, Y, Jia, W, Yun, J, Luo, R, Zheng, M

Oncotarget 2015
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Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-11)
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