miR-26A and B bind to the 3'UTR of the GREB1 mRNA

Stable Identifier
R-HSA-9011958
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Translation of GREB1 mRNA is negatively regulated by mIR-26A and B, which bind directly to the 3'UTR. mIR-26A and B are both downregulated in the presence of estrogen in a manner that depends on estrogen-stimulated MYC gene expression. Of the nine identified estrogen-responsive, mIR-26 regulated genes, GREB1, CHD1 and KPNA2 are the only three that contribute to the proliferative response to estrogen (Tan et al, 2014).

Literature References
PubMed ID Title Journal Year
24735615 Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2

Tan, S, Ding, K, Li, R, Zhang, W, Li, G, Kong, X, Qian, P, Lobie, PE, Zhu, T

Breast Cancer Res. 2014
Participants
Participant Of
Authored
Reviewed
Created
Cite Us!