DEXA:NR3C1 complex binds RUNX2 gene proximal promoter

Stable Identifier
R-HSA-9009085
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DEXA:NR3C1 complex binds RUNX2 gene proximal promoter
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Based on studies in mice, glucocorticoid receptor (NR3C1) activated by dexamethasone (DEXA) binds to glucocorticoid receptor response element (GRE) in the proximal (P2) promoter of the RUNX2 gene. NR3C1 may also recruit histone deacetylase HDAC1 to the RUNX2 promoter (Zhang et al. 2012). Similar to the mouse promoter, human RUNX2 P2 promoter also contains GREs.
Literature References
PubMed ID Title Journal Year
22422618 Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis

Huang, HY, Guo, L, He, Q, Liu, Y, Qian, SW, Ma, CG, Zhang, YY, Tang, QQ, Li, X

Mol. Endocrinol. 2012
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Nr3c1:DEXA binds Runx2 proximal promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-15)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-15)
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