Nr3c1:DEXA binds Runx2 proximal promoter

Stable Identifier
R-MMU-9009091
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Nr3c1:DEXA binds Runx2 proximal promoter

Endogenous mouse glucocorticoid receptor (Nr3c1), activated by dexamethasone (DEXA) binding, binds to a glucocorticoid receptor response element (GRE) in the proximal P2 promoter of the Runx2 gene. Nr3c1 may also recruit histone deacetylase Hdac1 to the Runx2 promoter (Zhang et al. 2012).

Literature References
PubMed ID Title Journal Year
22422618 Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis

Zhang, YY, Li, X, Qian, SW, Guo, L, Huang, HY, He, Q, Liu, Y, Ma, CG, Tang, QQ

Mol. Endocrinol. 2012
Participants
Orthologous Events
Authored
Reviewed
Created
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