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RUNX2 gene [nucleoplasm]
Stable Identifier
R-HSA-8939903
Type
DNA Sequence [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)
ESR1:estrogen:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)
DLX5,(DLX6):RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARG1CA binds the RUNX2 gene promoter (Homo sapiens)
ESRRA:PPARG1CA:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)
ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
MSX2 binds RUNX2 gene promoter (Homo sapiens)
MSX2:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
NKX3-2 binds RUNX2 gene promoter (Homo sapiens)
NKX3-2:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)
DLX5,(DLX6):RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
MSX2:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
NKX3-2:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P1:CBFB:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
ESR1:estrogen:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARG1CA:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P2:CBFB:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
TWIST1:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P1:CBFB:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P2 binds RUNX2 gene promoter (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P2:CBFB:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
TWIST1 binds the RUNX2 gene promoter (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
TWIST1:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
ENSEMBL:ENSG00000124813 RUNX2
Gene Names
RUNX2, AML3, CBFA1, OSF2, PEBP2A
Participates
as an input of
MSX2 binds RUNX2 gene promoter (Homo sapiens)
NKX3-2 binds RUNX2 gene promoter (Homo sapiens)
DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)
RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)
RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)
ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)
TWIST1 binds the RUNX2 gene promoter (Homo sapiens)
Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)
RUNX2-P2 binds RUNX2 gene promoter (Homo sapiens)
DEXA:NR3C1 complex binds RUNX2 gene proximal promoter (Homo sapiens)
ESRRA:PPARG1CA binds the RUNX2 gene promoter (Homo sapiens)
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
as a component of
MSX2:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P1:CBFB:RUNX2 gene [nucleoplasm] (Homo sapiens)
DLX5,(DLX6):RUNX2 gene [nucleoplasm] (Homo sapiens)
NKX3-2:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2-P2:CBFB:RUNX2 gene [nucleoplasm] (Homo sapiens)
Glucocorticoid ligand:NR3C1:RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARG1CB:RUNX2 gene [nucleoplasm] (Homo sapiens)
TWIST1:RUNX2 gene [nucleoplasm] (Homo sapiens)
ESRRA:PPARG1CA:RUNX2 gene [nucleoplasm] (Homo sapiens)
ESR1:estrogen:RUNX2 gene [nucleoplasm] (Homo sapiens)
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