ESR1 binds to TGFA gene promoter

Stable Identifier
R-HSA-9008267
Type
Reaction [binding]
Species
Homo sapiens
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Hormone-activated estrogen receptor (ER) binds with high affinity to specific DNA sequences, estrogen response elements (EREs), found in the regulatory regions of estrogen-responsive genes (Klinge CM 2001). The majority of known estrogen responsive genes contain imperfect EREs that differ from the consensus ERE sequence, 5′-GGTCAnnnTGACC-3′, by one or more base pairs. The individual ERE sequences were found to differentially induce changes in ER conformation that may influence the recruitment of specific coactivator proteins (Wood JR et al. 2001). The promoter of the TGFA gene has two imperfect EREs between -252 to -200 and an additional upstream sequence between -623 and -549. These elements confer estrogen-responsiveness to the promoter and are bound by ESR1 as assessed by electrophoretic mobility shift assay (Vyhidal et al, 2000).

Literature References
PubMed ID Title Journal Year
11452016 Estrogen receptor interaction with estrogen response elements

Klinge, CM

Nucleic Acids Res. 2001
11581164 Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein

Yahata, T, Shao, W, Endoh, H, Hur, J, Coser, KR, Sun, H, Ueda, Y, Kato, S, Isselbacher, KJ, Brown, M, Shioda, T

Genes Dev. 2001
10828826 Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site

Vyhlidal, C, Samudio, I, Kladde, MP, Safe, S

J. Mol. Endocrinol. 2000
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