Interleukin-38 signaling

Stable Identifier
Homo sapiens
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Interleukins are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 1 family member 10 (IL1F10, IL 38) is a member of the IL1 family (Lin et al. 2001, Bensen et al. 2001). IL1F10 is selectively produced by human apoptotic cells (Mora et al. 2016) and human epidermal keratinocytes (based on mRNA studies) (Boutet M A et al. 2016). IL1F10 can bind to interleukin 1 receptor like 2 (IL1RL2) and may result in the suppression of IL 17 and IL 22 and induction of IL 6 production (van de Veerdonk et al. 2012, Mora et al. 2016). IL1F10 is synthesized as precursors that require N terminal processing to attain full receptor agonist or antagonist function (Mora et al. 2016). Both full length (1 – 152 amino acids) and N terminal truncated (20 – 152 amino acids) IL1F10 can bind Interleukin 1 receptor accessory protein like 1 (IL1RAPL1) (Mora et al. 2016). The binding affinity of truncated IL1F10 is much higher than that of the full length. However, binding of the full length or truncated forms has distinct outcomes; the former induces IL6 and the latter suppresses IL6 via JNK and AP1 signaling (Mora et al. 2016).

Literature References
PubMed ID Title Journal Year
10882729 Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling

Born, TL, Garka, KE, Renshaw, BR, Smith, DE, Bertles, JS, Sims, JE

J. Biol. Chem. 2000
25873772 Role of IL-38 and its related cytokines in inflammation

Yuan, X, Li, Y, Peng, X, Li, M

Mediators Inflamm. 2015
11278614 Cloning and characterization of IL-1HY2, a novel interleukin-1 family member

Hansen, D, Haley-Vicente, D, Lin, H, Ford, JE, Mize, NK, Zhang, J, Bernal-Fussell, J, Schweighofer, K, Ho, AS, Pace, AM

J. Biol. Chem. 2001
11747621 Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14

Dawson, PA, Mychaleckyj, JC, Bowden, DW, Bensen, JT

J. Interferon Cytokine Res. 2001
26892022 Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses

Weigert, A, Putyrski, M, Frank, AC, Wittig, I, Brüne, B, Schlemmer, A, Han, Y, Ernst, A, Jung, M, Richter, F, Mora, J

J Mol Cell Biol 2016
22315422 IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

Dinarello, CA, Netea, MG, Azam, T, Wu, G, van de Veerdonk, FL, Hao, R, Kalabokis, V, Joosten, LA, Stoeckman, AK, van der Meer, JW, Boeckermann, AN

Proc. Natl. Acad. Sci. U.S.A. 2012
15123616 Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL

Khan, JA, Tong, L, O'Neill, LA, Brint, EK

J. Biol. Chem. 2004
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