Reactome | IL9 binds IL9R:JAK1 and IL2RG:JAK3

IL9 binds IL9R:JAK1 and IL2RG:JAK3

Stable Identifier

R-HSA-8963734

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

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Interleukin-9 (IL9) binds to the Interleukin-9 receptor (IL9R) and Cytokine common gamma chain subunit (IL2RG) forming a ligand-receptor complex (Kimura et al 1995, Nizsalóczki et al. 2014). IL2RG is essential for IL9 dependent growth signal transduction (Kimura et al. 1995). IL9R (glycoprotein of 64 kDa) has saturable and specific binding sites with a Kd of 100 pM (Renauld et al. 1992). IL9R colocalize with Interleukin-2 receptors and MHC molecules in lipid rafts of human T lymphoma cells so it is suggested that interactions within these membrane clusters could affect the assembly and signaling capability of the receptors (Nizsalóczki et al. 2014). Moreover, there is evidence that Tyrosine protein kinase JAK1 (JAK1) cooperates with Tyrosine protein kinase JAK3 (JAK3) in signaling through IL2RG-containing receptors (Haan et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21439476	Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors Haan, C, Rolvering, C, Raulf, F, Kapp, M, Drückes, P, Thoma, G, Behrmann, I, Zerwes, HG	Chem. Biol.	2011
25297818	Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells Nizsalóczki, E, Csomós, I, Nagy, P, Fazekas, Z, Goldman, CK, Waldmann, TA, Damjanovich, S, Vámosi, G, Mátyus, L, Bodnár, A	Chemphyschem	2014
7718508	Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex Kimura, Y, Takeshita, T, Kondo, M, Ishii, N, Nakamura, M, Van Snick, J, Sugamura, K	Int Immunol	1995
1376929	Expression cloning of the murine and human interleukin 9 receptor cDNAs Renauld, JC, Druez, C, Kermouni, A, Houssiau, F, Uyttenhove, C, Van Roost, E, Van Snick, J	Proc Natl Acad Sci U S A	1992