Reactome | PGM2L1:Mg2+ phosphorylates G6P to G1,6BP

PGM2L1:Mg2+ phosphorylates G6P to G1,6BP

Stable Identifier

R-HSA-8955760

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PGM2L1:Mg2+ phosphorylates G6P to G1,6BP

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1,3-bisphosphoglycerate (1,3BPG) is the first energy rich intermediate of glycolysis. Cytosolic glucose 1,6-bisphosphate synthase (PGM2L1) utilises 1,3BPG as a phosphate donor to phosphorylate a series of 1-phosphate sugars. Although 5- and 6-phosphate sugars are poor substrates for PGM2L1, glucose 6-phosphate (G6P) is the exception (Maliekal et al. 2007, Veiga-da-Cunha et al. 2008). PGM2L1 complexed with Mg2+ as cofactor, phosphorylates G6P to glucose 1,6-bisphosphate (G1,6BP), a cofactor for phosphomutases and a putative regulator of glycolysis. PGM2L1 is mainly expressed in brain where its activity is particularly high (Maliekal et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
18927083	Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase Maliekal, P, Matthijs, G, Vleugels, W, Veiga-da-Cunha, M, Van Schaftingen, E	J. Biol. Chem.	2008
17804405	Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family Maliekal, P, Veiga-da-Cunha, M, Sokolova, T, Van Schaftingen, E, Vertommen, D	J Biol Chem	2007