Reactome | MZT2B [cytosol]

MZT2B [cytosol]

Stable Identifier

R-HSA-8955057

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mitotic-spindle organizing protein 2B, MOZART2B, FAM128B, GCP8B, MZT2B_HUMAN

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
        
        Association of NuMA with microtubules (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        Translocation of NuMA to the centrosomes (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
        
        Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6NZ67 MZT2B

Gene Names

MZT2B, FAM128B, MOZART2B

Chain

chain:1-158

Reference Genes

BioGPS Gene:80097 MZT2B

COSMIC (genes):MZT2B MZT2B

CTD Gene:80097 MZT2B

dbSNP Gene:80097 MZT2B

ENSEMBL:ENSG00000152082 MZT2B

HGNC:25886 MZT2B

KEGG:hsa:80097 MZT2B

Monarch:80097 MZT2B

NCBI Gene:80097 MZT2B

OMIM:613450 MZT2B

UCSC:Q6NZ67 MZT2B

Reference Transcript

RefSeq:NM_025029.4 MZT2B

Other Identifiers

11720809_x_at

16885516

212995_PM_x_at

212995_x_at

2505387

2505388

2505389

2505391

2505392

2505393

2505394

2505395

2505396

2505397

2505398

2505399

2505400

2505402

2505403

2505405

2505406

2505407

2505408

2576561

2576564

2576568

2576571

2576572

2576573

80097

8045142

8045146

A_24_P212152

A_24_P259819

GE83050

GO:0000931

GO:0005515

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0043226

HMNXSV003014559

HMNXSV003037696

Hs.3343.4.A1_3p_a_at

ILMN_1717184

PH_hs_0017242

TC02000804.hg

Participates

as a component of

gamma-tubulin complex [cytosol] (Homo sapiens)

Inferred To

MZT2 [cytosol] (Bos taurus)

Mzt2 [cytosol] (Mus musculus)

mzt2b [cytosol] (Xenopus tropicalis)

LOC100153925 [cytosol] (Sus scrofa)

MZT2A [cytosol] (Gallus gallus)

MZT2B [cytosol] (Canis familiaris)

Mzt2b [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_079305.2

ENSEMBL

ENSP00000281871, ENSP00000517875, ENST00000709784, ENST00000281871

OpenTargets

ENSG00000152082

HPA

ENSG00000152082-MZT2B

PRO

Q6NZ67

Pharos - Targets

Q6NZ67

GlyGen

Q6NZ67

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P25090 FPR2	4	FPR2 [plasma membrane] (R-HSA-416408) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [tertiary granule membrane] (R-HSA-6803296)	0.527	2
UniProt:Q9Y6L6 SLCO1B1	3	SLCO1B1 R580* [plasma membrane] (R-HSA-5661185) SLCO1B1 R253* [plasma membrane] (R-HSA-5661200) SLCO1B1 [plasma membrane] (R-HSA-194133)	0.527	2