Reactome | MZT2B [cytosol]

MZT2B [cytosol]

Stable Identifier

R-HSA-8955057

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mitotic-spindle organizing protein 2B, MOZART2B, FAM128B, GCP8B, MZT2B_HUMAN

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
        
        Association of NuMA with microtubules (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        Translocation of NuMA to the centrosomes (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
        
        Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        MZT2B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6NZ67 MZT2B

Gene Names

MZT2B, FAM128B, MOZART2B

Chain

chain:1-158

Reference Genes

BioGPS Gene:80097 MZT2B

COSMIC (genes):MZT2B MZT2B

CTD Gene:80097 MZT2B

dbSNP Gene:80097 MZT2B

ENSEMBL:ENSG00000152082 MZT2B

HGNC:25886 MZT2B

KEGG Gene (Homo sapiens):80097 MZT2B

Monarch:80097 MZT2B

NCBI Gene:80097 MZT2B

OMIM:613450 MZT2B

UCSC:Q6NZ67 MZT2B

Reference Transcript

RefSeq:NM_025029.4 MZT2B

Other Identifiers

11720809_x_at

212995_x_at

2505391

2505392

2505394

2505395

2505402

2505403

2576561

2576572

2576573

80097

8045142

A_24_P212152

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0008274

GO:0032991

GO:0043226

HMNXSV003014559

Hs.3343.4.A1_3p_a_at

PH_hs_0017242

Participates

as a component of

gamma-tubulin complex [cytosol] (Homo sapiens)

Inferred To

mzt2 [cytosol] (Danio rerio)

Mzt2 [cytosol] (Mus musculus)

LOC100153925 [cytosol] (Sus scrofa)

MZT2B [cytosol] (Canis familiaris)

MZT2B [cytosol] (Gallus gallus)

Mzt2b [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_079305.2

Target Pathogen

5b354852be737e166372eaf5

OpenTargets

ENSG00000152082

HPA

ENSG00000152082-MZT2B

GeneCards

Q6NZ67

Ensembl

ENST00000281871, ENSG00000152082, ENSP00000281871

PRO

Q6NZ67