JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated

Stable Identifier
R-HSA-8950405
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
JAK2 and JAK1 activation after IL-35:IL35R interaction
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Interleukin 35 (IL35) may presumably signal via a complex that includes Tyrosine protein kinase JAK1 (JAK1) and JAK2 associated with Interleukin 6 receptor beta subunit (IL6ST) and Interleukin 12 receptor beta 2 subunit (IL12RB2) (Collison et al. 2012). These JAKs are believed to phosphorylate Signal transducer and activator of transcription 1 (STAT) (Stark GR and Darnell JE, 2012). As the series of events that induces JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA

Nat. Immunol. 2012
22814351 IL-12 family cytokines: immunological playmakers

Vignali, DA, Kuchroo, VK

Nat. Immunol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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