Reactome | JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated

JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated

Stable Identifier

R-HSA-8950405

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

JAK2 and JAK1 activation after IL-35:IL35R interaction

ReviewStatus

5/5

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JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated

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Interleukin 35 (IL35) may presumably signal via a complex that includes Tyrosine protein kinase JAK1 (JAK1) and JAK2 associated with Interleukin 6 receptor beta subunit (IL6ST) and Interleukin 12 receptor beta 2 subunit (IL12RB2) (Collison et al. 2012). These JAKs are believed to phosphorylate Signal transducer and activator of transcription 1 (STAT) (Stark GR and Darnell JE, 2012). As the series of events that induces JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References

PubMed ID	Title	Journal	Year
22814351	IL-12 family cytokines: immunological playmakers Vignali, DA, Kuchroo, VK	Nat. Immunol.	2012
22306691	The composition and signaling of the IL-35 receptor are unconventional Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA	Nat. Immunol.	2012