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IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane]
Stable Identifier
R-HSA-8950255
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22814351
IL-12 family cytokines: immunological playmakers
Vignali, DA
,
Kuchroo, VK
Nat. Immunol.
2012
Participants
components
IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35 [extracellular region] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
Participant Of
output
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
input
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
hasComponent
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane]
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane]
Inferred To
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Danio rerio)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Mus musculus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Rattus norvegicus)
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