p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18

Stable Identifier
R-HSA-8948143
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FUNDC1-mediated mitophagy is inhibited by its phosphorylation at the Tyr 18 position in the LIR motif by Src kinase under normoxia conditions. These phosphorylation events insure that FUNDC1 cannot bind LC3.

Literature References
PubMed ID Title Journal Year
24746696 A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy

Chen, G, Han, Z, Feng, D, Chen, Y, Chen, L, Wu, H, Huang, L, Zhou, C, Cai, X, Fu, C, Duan, L, Wang, X, Liu, L, Liu, X, Shen, Y, Zhu, Y, Chen, Q

Mol. Cell 2014
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [cytosol]

Orthologous Events
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