Reactome | p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18

p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18

Stable Identifier

R-HSA-8948143

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18

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FUNDC1-mediated mitophagy is inhibited by its phosphorylation at the Tyr 18 position in the LIR motif by Src kinase under normoxia conditions. These phosphorylation events insure that FUNDC1 cannot bind LC3.

Literature References

PubMed ID	Title	Journal	Year
24746696	A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy Cai, X, Feng, D, Chen, Q, Chen, Y, Han, Z, Chen, L, Duan, L, Fu, C, Huang, L, Wang, X, Liu, X, Liu, L, Wu, H, Shen, Y, Zhou, C, Zhu, Y, Chen, G	Mol. Cell	2014