Reactome | SP7 [nucleoplasm]

SP7 [nucleoplasm]

Stable Identifier

R-HSA-8939843

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor Sp7, SP7_HUMAN, OSX, Zinc finger protein osterix

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8TDD2 SP7

Gene Names

SP7, OSX

Chain

chain:1-431

Reference Genes

BioGPS Gene:121340 SP7

COSMIC - genes:SP7 SP7

CTD Gene:121340 SP7

dbSNP Gene:121340 SP7

ENSEMBL:ENSG00000170374 SP7

HGNC:17321 SP7

KEGG:hsa:121340 SP7

Monarch:121340 SP7

NCBI Gene:121340 SP7

OMIM:606633 SP7

UCSC:Q8TDD2 SP7

Reference Transcript

Other Identifiers

11730644_at

11730645_a_at

121340

1552340_3p_at

1552340_PM_at

1552340_at

16765315

3456158

3456162

3456163

3456164

3456166

3456167

3456168

3456169

3456172

70777_at

7963664

A_23_P317729

A_33_P3352664

GE563149

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001649

GO:0003677

GO:0005515

GO:0005634

GO:0005737

GO:0006355

GO:0006357

GO:0008270

GO:0009612

GO:0010467

GO:0017151

GO:0030154

GO:0032868

GO:0034224

GO:0045944

GO:0046872

GO:0060218

GO:0071344

GO:0071374

GO:0071529

GO:2000738

HMNXSV003049971

Hs2.209402.1.S1_3p_at

Hs2.209402.1.S1_3p_s_at

ILMN_1689461

PH_hs_0012172

TC12001548.hg

Participates

as a component of

RUNX2:CBFB:SP7:UCMA gene [nucleoplasm] (Homo sapiens)

as an input of

RUNX2 and SP7 bind the UCMA gene promoter (Homo sapiens)

Cross References

RefSeq

XP_054189114.1, NP_690599.1, XP_054227053.1, NP_001287766.1, NP_001166938.1

OpenTargets

ENSG00000170374

ENSEMBL

ENST00000708981, ENST00000303846, ENSG00000291837, ENSP00000443827, ENSP00000517442, ENSP00000441367, ENSP00000517441, ENSP00000517443, ENSP00000302812, ENSG00000170374, ENST00000536324, ENST00000708983, ENST00000537210, ENST00000708982

HPA

ENSG00000170374-SP7

GeneCards

SP7

PRO

Q8TDD2

Pharos - Targets

Q8TDD2

Orphanet

SP7

GlyGen

Q8TDD2

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95995 DRC4	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	5
UniProt:Q9H5Z6-2 FAM124B			0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	5
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.527	2
UniProt:O00712 NFIB	1	NFIB [nucleoplasm] (R-HSA-60136)	0.471	2
UniProt:P08651 NFIC	1	NFIC [nucleoplasm] (R-HSA-60138)	0.471	2
UniProt:Q12857 NFIA	1	NFIA [nucleoplasm] (R-HSA-60134)	0.471	2
UniProt:P49841 GSK3B	5	GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [endoplasmic reticulum lumen] (R-HSA-9931408) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.463	2