Based on mouse studies, RUNX2, presumably associated with CBFB, and SP7 (also known as Osterix or OSX), bind to adjacent RUNX2 and OSX binding sites, respectively, in the promoter of the UCMA gene. RUNX2 and OSX binding sites in the UCMA promoter are evolutionarily conserved. It is not clear whether RUNX2 and SP7 directly physically interact (Lee et al. 2015).
Lee, SJ, Park, SY, Kim, JE, Boo, YC, Lee, YJ, Choi, JY
© 2022 Reactome