RUNX2 and SP7 bind the UCMA gene promoter

Stable Identifier
R-HSA-8939852
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2 and SP7 bind the UCMA gene promoter
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Based on mouse studies, RUNX2, presumably associated with CBFB, and SP7 (also known as Osterix or OSX), bind to adjacent RUNX2 and OSX binding sites, respectively, in the promoter of the UCMA gene. RUNX2 and OSX binding sites in the UCMA promoter are evolutionarily conserved. It is not clear whether RUNX2 and SP7 directly physically interact (Lee et al. 2015).
Literature References
PubMed ID Title Journal Year
25865393 Ucma, a direct transcriptional target of Runx2 and Osterix, promotes osteoblast differentiation and nodule formation

Lee, SJ, Park, SY, Kim, JE, Boo, YC, Lee, YJ, Choi, JY

Osteoarthr. Cartil. 2015
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Runx2:Cbfb and Sp7 bind the Ucma gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2016-09-21)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-21)
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