LIFR gene expression

Stable Identifier
R-HSA-8934690
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LIFR gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of the RUNX1:CBFB complex to the promoter of the LIFR gene stimulates LIFR transcription. In contrast, the oncogenic fusion protein RUNX1-ETO, the product of t(8;21) translocation in acute myeloid leukemia (AML), represses transcription of the LIFR gene (Qadi et al. 2016). LIFR encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 (IL6) cytokine family. Signaling by LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola and Babon 2015).
Literature References
PubMed ID Title Journal Year
26060100 The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1

Holloway, AF, Taberlay, PC, Dickinson, JL, Young, A, West, AC, Phillips, JL, Qadi, AA, Brettingham-Moore, KH

J. Cell. Biochem. 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:LIFR gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-08-11)
Cite Us!