IL3 gene transcription is stimulated by RUNX1 and ELF1

Stable Identifier
R-HSA-8938981
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL3 gene transcription is stimulated by RUNX1 and ELF1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of the RUNX1:CBFB complex associated with ELF1, an ETS family member, to the promoter of the IL3 gene, encoding interleukin-3, stimulates IL3 transcription (Mao et al. 1999).

Literature References
PubMed ID Title Journal Year
10207087 Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

Miyazaki, Y, Zhang, J, Nimer, SD, Mao, S, Frank, RC

Mol. Cell. Biol. 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:ELF1:IL3 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB:ELF1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-14)
Cite Us!