Reactome | IL3 [extracellular region]

IL3 [extracellular region]

Stable Identifier

R-HSA-450059

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-3, IL3_HUMAN

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Phosphorylated SHC1 recruits SHIP (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - 14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - Activation of STAT5a/b by JAK2 (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - IL3RB is phosphorylated on Ser-585 (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Phosphorylated SHC1 recruits SHIP (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - JAK2 is phosphorylated, activated (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - SHP1 and SHP2 bind the common beta chain (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, p(Y593)-Bc [plasma membrane] (Homo sapiens)
        
        IL3RA:IL3:p(Y593)-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - STAT5 is recruited by JAK2 (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - The receptor is activated (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - Tyrosine kinases phosphorylate the receptor (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
      - p-STAT5 dissociates from the receptor complex (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
        
        IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
        
        IL3:IL3RA [plasma membrane] (Homo sapiens)
        
        IL3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08700 IL3

Gene Names

IL3

Chain

signal peptide:1-19, chain:20-152

Reference Genes

BioGPS Gene:3562 IL3

COSMIC (genes):IL3 IL3

CTD Gene:3562 IL3

dbSNP Gene:3562 IL3

ENSEMBL:ENSG00000164399 IL3

HGNC:6011 IL3

KEGG:hsa:3562 IL3

Monarch:3562 IL3

NCBI Gene:3562 IL3

OMIM:147740 IL3

UCSC:P08700 IL3

Reference Transcript

RefSeq:NM_000588.3 IL3

Other Identifiers

11732963_at

1263_at

16988964

207906_PM_at

207906_at

2828324

2828325

2828326

2828327

2828329

2828331

2828332

2828333

2828335

3562

8107878

A_14_P110601

A_23_P348831

A_33_P3419264

GE533942

GO:0002376

GO:0005125

GO:0005135

GO:0005515

GO:0005576

GO:0005615

GO:0006955

GO:0007267

GO:0007399

GO:0008083

GO:0008284

GO:0023052

GO:0035162

GO:0038156

GO:0042531

GO:0048018

GO:0048856

GO:0050731

GO:0098772

HMNXSV003054020

ILMN_1766320

M20137_at

PH_hs_0000079

TC05000628.hg

g4504666_3p_at

Participates

as an output of

IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)

as an input of

Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)

as a component of

IL3:IL3RA [plasma membrane] (Homo sapiens)

Inferred To

Ghost homologue of IL3 [extracellular region] (Gallus gallus)

Il3 [extracellular region] (Mus musculus)

Il3 [extracellular region] (Rattus norvegicus)

IL3 [extracellular region] (Bos taurus)

IL3 [extracellular region] (Canis familiaris)

Cross References

RefSeq

NP_000579.2

ENSEMBL

ENSP00000296870, ENST00000296870

OpenTargets

ENSG00000164399

HPA

ENSG00000164399-IL3

PRO

P08700

Pharos - Targets

P08700

GlyGen

P08700

HMDB Protein

HMDBP02287

PDB

5UWC, 1JLI, 5UV8, 6NMY

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26951-1 IL3RA			0.611	5
UniProt:P32927 CSF2RB	6	p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.589	2

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