RUNX3 translocates to the nucleus

Stable Identifier
R-HSA-8937814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Translocation of RUNX3 from the cytosol to the nucleus is stimulated by TGF-beta (TGFB1) treatment (Ito et al. 2005) and inhibited by SRC-mediated phosphorylation of RUNX3 on multiple tyrosine residues (Goh et al. 2010).

Literature References
PubMed ID Title Journal Year
16140942 RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization

Ito, K, Liu, Q, Salto-Tellez, M, Yano, T, Tada, K, Ida, H, Huang, C, Shah, N, Inoue, M, Rajnakova, A, Hiong, KC, Peh, BK, Han, HC, Ito, T, Teh, M, Yeoh, KG, Ito, Y

Cancer Res. 2005
20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm

Goh, YM, Cinghu, S, Hong, ET, Lee, YS, Kim, JH, Jang, JW, Li, YH, Chi, XZ, Lee, KS, Wee, H, Ito, Y, Oh, BC, Bae, SC

J. Biol. Chem. 2010
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