RUNX3 translocates to the nucleus

Stable Identifier
Reaction [transition]
Homo sapiens
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Translocation of RUNX3 from the cytosol to the nucleus is stimulated by TGF-beta (TGFB1) treatment (Ito et al. 2005) and inhibited by SRC-mediated phosphorylation of RUNX3 on multiple tyrosine residues (Goh et al. 2010).

Literature References
PubMed ID Title Journal Year
20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm

Cinghu, S, Lee, KS, Lee, YS, Kim, JH, Goh, YM, Hong, ET, Bae, SC, Jang, JW, Ito, Y, Chi, XZ, Oh, BC, Li, YH, Wee, H

J. Biol. Chem. 2010
16140942 RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization

Yano, T, Salto-Tellez, M, Ida, H, Ito, K, Ito, Y, Peh, BK, Han, HC, Hiong, KC, Huang, C, Tada, K, Rajnakova, A, Inoue, M, Ito, T, Yeoh, KG, Teh, M, Shah, N, Liu, Q

Cancer Res. 2005
This event is regulated