Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter

Stable Identifier
R-HSA-8937050
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The WDR5-containing histone methyltransferase MLL complex, recruited to the MIR27A promoter via RUNX1 (and possibly GATA1), methylates histone H3 on dimethylated lysine residue K4 (K5 when taking into account the initiator methionine), producing the H3K4me3 mark. The H3K4me3 mark is characteristic of nucleosome associated with transcriptionally active promoters of megakaryocyte-specific genes (Herglotz et al. 2013).

Literature References
PubMed ID Title Journal Year
22777353 Histone arginine methylation keeps RUNX1 target genes in an intermediate state Oncogene 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
Physical Entity
Activity
Orthologous Events