Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter

Stable Identifier
Reaction [transition]
Homo sapiens
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The WDR5-containing histone methyltransferase MLL complex, recruited to the THBS1 (TSP-1) promoter via RUNX1 (and possibly GATA1), is assumed to methylate histone H3 on dimethylated lysine residue K4 (K5 when taking into account the initiator methionine), producing the H3K4me3 mark. The H3K4me3 mark is characteristic of nucleosome associated with transcriptionally active promoters of megakaryocyte-specific genes (Herglotz et al. 2013) and the appearance of the H3K4me3 mark at the THBS1 promoter coincides with THBS1 transactivation (Michaud-Levesque and Richard 2009).

Literature References
PubMed ID Title Journal Year
19509293 Thrombospondin-1 is a transcriptional repression target of PRMT6

Michaud-Levesque, J, Richard, S

J. Biol. Chem. 2009
22777353 Histone arginine methylation keeps RUNX1 target genes in an intermediate state

Hussong, H, Herglotz, J, Kolodziej, S, Grez, M, Kuvardina, ON, Kumar, A, Lausen, J

Oncogene 2013
Catalyst Activity

histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]

Orthologous Events
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