RUNX1 regulates expression of components of tight junctions

Stable Identifier
R-HSA-8935964
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX1 regulates expression of components of tight junctions
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The RUNX1 transcription factor, which functions as part of the RUNX1:CBFB complex, was shown to directly transcriptionally regulate expression of several genes that encode components of tight junctions. Namely, RUNX1 binds to promoters of TJP1 (encoding ZO-1), OCLDN (encoding Occludin) and CLDN5 (encoding Claudin-5) and stimulates their transcription. Downregulation of RUNX1 by microRNA miR-18a negatively regulates expression of these three tight junction genes, which may affect the permeability of blood-tumor barrier in glioma (Miao et al. 2015).
Literature References
PubMed ID Title Journal Year
25452107 MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5

Xue, YX, Wang, P, Zhao, YY, Miao, YS, Ma, J, Liu, YH, Zhao, LN

Cell. Signal. 2015
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Go Biological Process
regulation of bicellular tight junction assembly (2000810)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-08-15)
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