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RUNX1 binds the OCLN gene promoter
Stable Identifier
R-HSA-8935980
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates expression of components of tight junctions (Homo sapiens)
RUNX1 binds the OCLN gene promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The RUNX1:CBFB complex binds to the promoter of the OCLN gene, encoding Occludin, a component of the tight junction (Miao et al. 2015).
Literature References
PubMed ID
Title
Journal
Year
25452107
MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5
Xue, YX
,
Wang, P
,
Zhao, YY
,
Miao, YS
,
Ma, J
,
Liu, YH
,
Zhao, LN
Cell. Signal.
2015
Participants
Input
OCLN gene [nucleoplasm]
(Homo sapiens)
RUNX1:CBFB [nucleoplasm]
(Homo sapiens)
Output
RUNX1:CBFB:OCLN gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RUNX1 regulates expression of components of tight junctions (Homo sapiens)
Authored
Orlic-Milacic, M (2016-09-14)
Reviewed
Chuang, LS (2016-12-20)
Ito, Y (2016-12-20)
Created
Orlic-Milacic, M (2016-08-15)
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