PXLP-K405-GAD1 decarboxylates L-Glu to form GABA

Stable Identifier
R-HSA-888572
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Synthesis of GABA by GAD1
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GAD1 (GAD67) is evenly spread throughout the neuronal cytoplasm and is invoved in GABA synthesis that is used for synaptogenesis, protection against neural injury and as an energy source through the GABA shunt.

Literature References
PubMed ID Title Journal Year
16759710 Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders

Akbarian, S, Huang, HS

Brain Res Rev 2006
17767149 Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

Straub, RE, Lipska, BK, Egan, MF, Goldberg, TE, Callicott, JH, Mayhew, MB, Vakkalanka, RK, Kolachana, BS, Kleinman, JE, Weinberger, DR

Mol Psychiatry 2007
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glutamate decarboxylase activity of PXLP-K405-GAD1 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created