Reactome | PXLP-K405-GAD1 decarboxylates L-Glu to form GABA

PXLP-K405-GAD1 decarboxylates L-Glu to form GABA

Stable Identifier

R-HSA-888572

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Synthesis of GABA by GAD1

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PXLP-K405-GAD1 decarboxylates L-Glu to form GABA

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GAD1 (GAD67) is evenly spread throughout the neuronal cytoplasm and is invoved in GABA synthesis that is used for synaptogenesis, protection against neural injury and as an energy source through the GABA shunt.

Literature References

PubMed ID	Title	Journal	Year
16759710	Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders Akbarian, S, Huang, HS	Brain Res Rev	2006
17767149	Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression Straub, RE, Lipska, BK, Egan, MF, Goldberg, TE, Callicott, JH, Mayhew, MB, Vakkalanka, RK, Kolachana, BS, Kleinman, JE, Weinberger, DR	Mol Psychiatry	2007