Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GABA synthesis
Stable Identifier
R-HSA-888568
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA synthesis (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
GABA synthesized uniquely by two forms of glutamate decarboxylases, GAD65 and GAD67, that are functionally distinct and have different co-factor requirements. GAD65 is functionally linked to VGAT, the GABA transporter and selectively GABA synthesized by GAD65 is preferably loaded into the synaptic vesicles. GABA synthesized by GAD67 may be used for functions other than nuerotransmission.
Literature References
PubMed ID
Title
Journal
Year
12467378
GABA and glutamate in the human brain
Petroff, OA
Neuroscientist
2002
9777630
Are GAD65 and GAD67 associated with specific pools of GABA in brain?
Barke, KE
,
Martin, DL
Perspect Dev Neurobiol
1998
9871412
Two isoforms of glutamate decarboxylase: why?
Soghomonian, JJ
,
Martin, DL
Trends Pharmacol Sci
1998
Participants
Events
PXLP-K405-GAD1 decarboxylates L-Glu to form GABA
(Homo sapiens)
Synthesis of GABA by GAD2
(Homo sapiens)
Participates
as an event of
GABA synthesis, release, reuptake and degradation (Homo sapiens)
Event Information
Go Biological Process
gamma-aminobutyric acid biosynthetic process (0009449)
Orthologous Events
GABA synthesis (Bos taurus)
GABA synthesis (Caenorhabditis elegans)
GABA synthesis (Canis familiaris)
GABA synthesis (Danio rerio)
GABA synthesis (Drosophila melanogaster)
GABA synthesis (Gallus gallus)
GABA synthesis (Mus musculus)
GABA synthesis (Rattus norvegicus)
GABA synthesis (Sus scrofa)
GABA synthesis (Xenopus tropicalis)
Authored
Mahajan, SS (2010-06-30)
Reviewed
Restituito, S (2008-11-27)
Created
Mahajan, SS (2010-06-30)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text