GABA synthesis

Stable Identifier
R-HSA-888568
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
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GABA synthesis
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GABA synthesized uniquely by two forms of glutamate decarboxylases, GAD65 and GAD67, that are functionally distinct and have different co-factor requirements. GAD65 is functionally linked to VGAT, the GABA transporter and selectively GABA synthesized by GAD65 is preferably loaded into the synaptic vesicles. GABA synthesized by GAD67 may be used for functions other than nuerotransmission.

Literature References
PubMed ID Title Journal Year
9777630 Are GAD65 and GAD67 associated with specific pools of GABA in brain?

Martin, DL, Barke, KE

Perspect Dev Neurobiol 1998
12467378 GABA and glutamate in the human brain

Petroff, OA

Neuroscientist 2002
9871412 Two isoforms of glutamate decarboxylase: why?

Soghomonian, JJ, Martin, DL

Trends Pharmacol Sci 1998
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
gamma-aminobutyric acid biosynthetic process (0009449)
Orthologous Events
GABA synthesis (Bos taurus)
GABA synthesis (Caenorhabditis elegans)
GABA synthesis (Danio rerio)
GABA synthesis (Drosophila melanogaster)
GABA synthesis (Gallus gallus)
GABA synthesis (Mus musculus)
GABA synthesis (Rattus norvegicus)
GABA synthesis (Sus scrofa)
GABA synthesis (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-06-30)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-06-30)
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