Reactome | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Stable Identifier

R-HSA-8939243

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

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The transcriptional activity of the RUNX1:CBFB complex is regulated by interaction with co-factors and posttranslational modifications of RUNX1. Protein serine/threonine kinase HIPK2 can phosphorylate RUNX1 and affect transcriptional activity of the RUNX1:CBFB complex during hematopoiesis. Some CBFB mutations found in leukemia interfere with HIPK2-mediated phosphorylation of RUNX1. HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300) bound to the RUNX1:CBFB1 complex (Aikawa et al. 2006, Wee et al. 2008).
The RUNX1:CBFB complex can associate with the polycomb repressor complex 1 (PRC1). PRC1 complexes are found at many RUNX1 target promoters and can act either as co-activators or co-repressors in the transactivation of RUNX1 targets (Yu et al. 2011).
RUNX1 recruits the SWI/SNF chromatin remodeling complex to many RUNX1 target promoters by directly interacting with several SWI/SNF subunits (Bakshi et al. 2010).
Other co-factors of the RUNX1:CBFB complex are annotated in the context of transcriptional regulation of specific genes.

Literature References

PubMed ID	Title	Journal	Year
22325351	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors Yu, M, Mazor, T, Huang, H, Huang, HT, Kathrein, KL, Woo, AJ, Chouinard, CR, Labadorf, A, Akie, TE, Moran, TB, Xie, H, Zacharek, S, Taniuchi, I, Roeder, RG, Kim, CF, Zon, LI, Fraenkel, E, Cantor, AB	Mol. Cell	2012
18695000	PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis Wee, HJ, Voon, DC, Bae, SC, Ito, Y	Blood	2008
20506188	The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes Bakshi, R, Hassan, MQ, Pratap, J, Lian, JB, Montecino, MA, van Wijnen, AJ, Stein, JL, Imbalzano, AN, Stein, GS	J. Cell. Physiol.	2010
16917507	Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation Aikawa, Y, Nguyen, LA, Isono, K, Takakura, N, Tagata, Y, Schmitz, ML, Koseki, H, Kitabayashi, I	EMBO J.	2006