Reactome | PI5P Regulates TP53 Acetylation

PI5P Regulates TP53 Acetylation

Stable Identifier

R-HSA-6811555

DOI

10.3180/R-HSA-6811555.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)

General

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Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 binds TP53 (p53) and recruits histone acetyltransferase EP300 (p300) to TP53, leading to TP53 acetylation. Increased nuclear PI5P levels positively regulate TP53 acetylation (Ciruela et al. 2000, Gozani et al. 2003, Jones et al. 2006, Zou et al. 2007, Bultsma et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
16949365	Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta Jones, DR, D'Santos, CS, Bultsma, Y, Heck, AJ, Keune, WJ, Halstead, JR, Divecha, N, Mohammed, S, Elouarrat, D	Mol. Cell	2006
17940011	Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, M, Zou, J	Proc. Natl. Acad. Sci. U.S.A.	2007
12859901	The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor Ivanov, D, Jones, DR, Zhu, H, Baird, CL, Lessnick, SL, Gozani, O, Mehrotra, B, Prestwich, GD, Wagner, G, Myszka, DG, Ferguson, CG, Field, SJ, Cantley, LC, Lugovskoy, AA, Cha, J, Karuman, P, Payrastre, B, Brugge, JS, Yuan, J, Villasenor, J, Divecha, N, Rao, VR, Chen, J	Cell	2003
10698683	Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7 Ciruela, A, Irvine, RF, Hinchliffe, KA, Divecha, N	Biochem. J.	2000
20583997	PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha Bultsma, Y, Keune, WJ, Divecha, N	Biochem. J.	2010