PI5P Regulates TP53 Acetylation

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R-HSA-6811555
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Pathway
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Homo sapiens
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Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 binds TP53 (p53) and recruits histone acetyltransferase EP300 (p300) to TP53, leading to TP53 acetylation. Increased nuclear PI5P levels positively regulate TP53 acetylation (Ciruela et al. 2000, Gozani et al. 2003, Jones et al. 2006, Zou et al. 2007, Bultsma et al. 2010).

Literature References
PubMed ID Title Journal Year
17940011 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

Zou, J, Marjanovic, J, Kisseleva, MV, Wilson, M, Majerus, PW

Proc. Natl. Acad. Sci. U.S.A. 2007
16949365 Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta

Jones, DR, Bultsma, Y, Keune, WJ, Halstead, JR, Elouarrat, D, Mohammed, S, Heck, AJ, D'Santos, CS, Divecha, N

Mol. Cell 2006
12859901 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

Gozani, O, Karuman, P, Jones, DR, Ivanov, D, Cha, J, Lugovskoy, AA, Baird, CL, Zhu, H, Field, SJ, Lessnick, SL, Villasenor, J, Mehrotra, B, Chen, J, Rao, VR, Brugge, JS, Ferguson, CG, Payrastre, B, Myszka, DG, Cantley, LC, Wagner, G, Divecha, N, Prestwich, GD, Yuan, J

Cell 2003
10698683 Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7

Ciruela, A, Hinchliffe, KA, Divecha, N, Irvine, RF

Biochem. J. 2000
20583997 PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha

Bultsma, Y, Keune, WJ, Divecha, N

Biochem. J. 2010
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