Reactome | ECE1 cleaves EDN1(53-90)

ECE1 cleaves EDN1(53-90)

Stable Identifier

R-HSA-8876868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Endothelin-converting enzyme 1 (ECE1) is a type II membrane-bound zinc metalloprotease. It cleaves the longer form of endothelin (EDN1(53-90), also known as Big ET-1, by an unusual selective hydrolysis of Trp21-Val22, producing EDN1. ECE1 exhibits maximal activity at pH 7.0. It comprises a short cytoplasmic N-terminal tail, a membrane-spanning region, and a large extracellular domain containing a zinc-binding motif essential for enzymatic activity (Schweizer et al. 1997, Valdenaire et al.1999, Jeng et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8062389	ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 Slaughter, C, Emoto, N, Giaid, A, Yanagisawa, M, Kaw, S, deWit, D, Xu, D	Cell	1994