ECE1 cleaves EDN1(53-90)

Stable Identifier
R-HSA-8876868
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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ECE1 cleaves EDN1(53-90)
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Endothelin-converting enzyme 1 (ECE1) is a type II membrane-bound zinc metalloprotease. It cleaves the longer form of endothelin (EDN1(53-90), also known as Big ET-1, by an unusual selective hydrolysis of Trp21-Val22, producing EDN1. ECE1 exhibits maximal activity at pH 7.0. It comprises a short cytoplasmic N-terminal tail, a membrane-spanning region, and a large extracellular domain containing a zinc-binding motif essential for enzymatic activity (Schweizer et al. 1997, Valdenaire et al.1999, Jeng et al. 2002).
Literature References
PubMed ID Title Journal Year
8062389 ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Xu, D, Emoto, N, Giaid, A, Slaughter, C, Kaw, S, deWit, D, Yanagisawa, M

Cell 1994
Participants
Input
Output
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as an event of
Catalyst Activity

metalloendopeptidase activity of ECE1 [plasma membrane]

Physical Entity
ECE1 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
ECE1 cleaves EDN1(53-90) (Bos taurus)
ECE1 cleaves EDN1(53-90) (Canis familiaris)
ECE1 cleaves EDN1(53-90) (Danio rerio)
ECE1 cleaves EDN1(53-90) (Mus musculus)
ECE1 cleaves EDN1(53-90) (Rattus norvegicus)
ECE1 cleaves EDN1(53-90) (Sus scrofa)
ECE1 cleaves EDN1(53-90) (Xenopus tropicalis)
Authored
Jupe, S  (2016-05-23)
Reviewed
D'Eustachio, P  (2016-11-15)
Created
Jupe, S  (2016-06-17)
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