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EDN1 [extracellular region]
Stable Identifier
R-HSA-388545
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
ET1, RecName: Full=Endothelin-1; AltName: Full=Preproendothelin-1; Short=PPET1; Contains: RecName: Full=Endothelin-1; Short=ET-1; Contains: RecName: Full=Big endothelin-1; Flags: Precursor; GN Name=EDN1; OS Homo sapiens, EDN1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MITF gene expression (Homo sapiens)
EDN1, EDN3:EDNRB [plasma membrane] (Homo sapiens)
EDN1, EDN3 [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development (Homo sapiens)
EDN1, EDN3:EDNRB [plasma membrane] (Homo sapiens)
EDN1, EDN3 [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
ECE1 cleaves EDN1(53-90) (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
EDNRA binds EDNs (Homo sapiens)
EDNRA:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
EDNRA,EDNRB bind EDNs (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05305 EDN1
Gene Names
EDN1
Chain
signal peptide:1-17, propeptide:18-50, peptide:53-90, peptide:53-73, propeptide:74-212
Reference Genes
BioGPS Gene:1906 EDN1
COSMIC (genes):EDN1 EDN1
CTD Gene:1906 EDN1
dbSNP Gene:1906 EDN1
ENSEMBL:ENSG00000078401 EDN1
HGNC:3176 EDN1
KEGG:hsa:1906 EDN1
Monarch:1906 EDN1
NCBI Gene:1906 EDN1
OMIM:131240 EDN1
UCSC:P05305 EDN1
Reference Transcript
RefSeq:XM_011514330.2 EDN1
RefSeq:XM_017010331.1 EDN1
RefSeq:NM_001168319.1 EDN1
RefSeq:NM_001955.4 EDN1
RefSeq:XM_011514331.2 EDN1
Other Identifiers
11726023_a_at
11726024_at
17004903
1906
218995_PM_s_at
218995_s_at
222802_PM_at
222802_at
2895247
2895248
2895250
2895252
2895254
2895256
2895257
8116921
A_14_P107424
A_23_P214821
A_33_P3258392
GE57521
GO:0000122
GO:0000165
GO:0001501
GO:0001516
GO:0001569
GO:0001666
GO:0001701
GO:0001821
GO:0001975
GO:0002376
GO:0003012
GO:0003013
GO:0003014
GO:0003015
GO:0003094
GO:0003100
GO:0003253
GO:0003357
GO:0005102
GO:0005125
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006351
GO:0006355
GO:0006366
GO:0006629
GO:0006874
GO:0006885
GO:0006939
GO:0007005
GO:0007166
GO:0007186
GO:0007193
GO:0007200
GO:0007204
GO:0007267
GO:0007411
GO:0007507
GO:0007585
GO:0007589
GO:0008217
GO:0008284
GO:0009410
GO:0009953
GO:0010193
GO:0010460
GO:0010467
GO:0010595
GO:0010613
GO:0010629
GO:0010827
GO:0014032
GO:0014033
GO:0014034
GO:0014823
GO:0014824
GO:0014826
GO:0019229
GO:0019722
GO:0022414
GO:0023052
GO:0030072
GO:0030133
GO:0030154
GO:0030185
GO:0030195
GO:0030335
GO:0030878
GO:0031175
GO:0031410
GO:0031583
GO:0031707
GO:0031708
GO:0032308
GO:0032496
GO:0033093
GO:0033574
GO:0034392
GO:0034696
GO:0035050
GO:0035094
GO:0035556
GO:0035810
GO:0035815
GO:0035994
GO:0042045
GO:0042310
GO:0042313
GO:0042474
GO:0042482
GO:0042554
GO:0043123
GO:0043179
GO:0043200
GO:0043226
GO:0043406
GO:0043491
GO:0043507
GO:0044321
GO:0044751
GO:0045178
GO:0045321
GO:0045429
GO:0045793
GO:0045840
GO:0045944
GO:0045987
GO:0046887
GO:0046888
GO:0048018
GO:0048237
GO:0048514
GO:0048661
GO:0048675
GO:0048856
GO:0048870
GO:0050850
GO:0050886
GO:0051091
GO:0051216
GO:0051248
GO:0051771
GO:0051899
GO:0055085
GO:0060070
GO:0060137
GO:0060298
GO:0060385
GO:0060585
GO:0061051
GO:0061626
GO:0070101
GO:0070294
GO:0070301
GO:0070371
GO:0070588
GO:0071277
GO:0071346
GO:0071347
GO:0071356
GO:0071372
GO:0071373
GO:0071375
GO:0071385
GO:0071389
GO:0071398
GO:0071456
GO:0071466
GO:0071548
GO:0071559
GO:0071560
GO:0072011
GO:0072112
GO:0086100
GO:0086101
GO:0090023
GO:0097492
GO:0098772
GO:0141156
GO:1900182
GO:1901224
GO:1902074
GO:1902287
GO:1903537
GO:1904707
GO:1905653
GO:2000273
GO:2001259
HMNXSV003026833
Hs.2271.0.S2_3p_at
ILMN_1682775
J05008_at
PH_hs_0026662
TC06000087.hg
g4503460_3p_a_at
Participates
as a member of
EDN1, EDN3 [extracellular region] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
as an output of
ECE1 cleaves EDN1(53-90) (Homo sapiens)
Other forms of this molecule
EDN1(53-90) [extracellular region]
EDN1 [transport vesicle]
EDN1(53-90) [transport vesicle]
Inferred To
edn1 [extracellular region]
(Danio rerio)
edn1 [extracellular region]
(Xenopus tropicalis)
Edn1 [extracellular region]
(Mus musculus)
Edn1 [extracellular region]
(Rattus norvegicus)
EDN1 [extracellular region]
(Bos taurus)
EDN1 [extracellular region]
(Canis familiaris)
EDN1 [extracellular region]
(Gallus gallus)
EDN1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
XP_011512632.1
,
NP_001161791.1
,
XP_011512633.1
,
NP_001946.3
,
XP_016865820.1
ENSEMBL
ENSP00000368683
,
ENST00000379375
OpenTargets
ENSG00000078401
HPA
ENSG00000078401-EDN1
PRO
P05305
Pharos - Targets
P05305
GlyGen
P05305
Orphanet
EDN1
HMDB Protein
HMDBP02088
PDB
8XGR
,
6DK5
,
8HCX
,
8IY5
,
8HCQ
,
8IY6
,
5GLH
,
1EDN
,
1T7H
,
1V6R
,
1EDP
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