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CBL binds InlB-activated MET
Stable Identifier
R-HSA-8876240
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane
,
peptidoglycan-based cell wall
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
CBL binds InlB-activated MET (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GRB2 is needed for the recruitment of CBL to the complex of Listeria monocytogenes InlB protein and phosphorylated MET receptor (Veiga and Cossart 2005).
Literature References
PubMed ID
Title
Journal
Year
16113677
Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells
Veiga, E
,
Cossart, P
Nat. Cell Biol.
2005
Participants
Input
CBL:GRB2 [cytosol]
(Homo sapiens)
InlB:p-4Y-MET dimer [plasma membrane]
(Homo sapiens)
Output
InlB:p-4Y-MET dimer:GRB2-1:CBL [plasma membrane]
(Homo sapiens)
Entity On Other Cell
InlB [peptidoglycan-based cell wall]
(Listeria monocytogenes)
Participates
as an event of
InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
Disease
Name
Identifier
Synonyms
listeriosis
DOID:11573
Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M (2016-06-14)
Reviewed
Schwerk, C (2016-10-25)
Created
Orlic-Milacic, M (2016-06-10)
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