InlB-mediated entry of Listeria monocytogenes into host cell

Stable Identifier
Homo sapiens
Related Species
Listeria monocytogenes
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InlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist (Shen et al. 2000, Veiga and Cossart 2005). Listeria monocytogenes InlB proteins dimerize through their leucine-rich repeat regions (LRRs), promoting dimerization of MET receptors that they are bound to (Ferraris et al. 2010). InlB-induced MET receptor dimerization is followed by MET trans-autophosphorylation and activation of downstream RAS/RAF/MAPK signaling and PI3K/AKT signaling (Niemann et al. 2007, Ferraris et al. 2010). InlB-bound phosphorylated MET receptor recruits the E3 ubiquitin ligase CBL through GRB2. CBL-mediated monoubiquitination of InlB-bound MET promotes endocytosis and entry of Listeria monocytogenes to host cells (Veiga and Cossart 2005). CIN85 is necessary for endocytosis-mediated entry of Listeria monocytogenes triggered by CBL-mediated monoubiquitination of MET (Veiga and Cossart 2005). Proteins involved in clathrin-mediated endocytosis EPS15 and HGS (Hrs) are both necessary for CBL and MET-mediated entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
A potential coreceptor role of CD44 in InlB-mediated MET activation is contradictory (Jung et al. 2009, Dortet et al. 2010).

Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
19900460 Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB

Ferraris, DM, Gherardi, E, Di, Y, Heinz, DW, Niemann, HH

J. Mol. Biol. 2010
11081636 InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase

Shen, Y, Naujokas, M, Park, M, Ireton, K

Cell 2000
17662939 Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB

Niemann, HH, J├Ąger, V, Butler, PJ, van den Heuvel, J, Schmidt, S, Ferraris, D, Gherardi, E, Heinz, DW

Cell 2007
19432801 Involvement of CD44v6 in InlB-dependent Listeria invasion

Jung, C, Matzke, A, Niemann, HH, Schwerk, C, Tenenbaum, T, Orian-Rousseau, V

Mol. Microbiol. 2009
20670691 CD44-independent activation of the Met signaling pathway by HGF and InlB

Dortet, L, Veiga, E, Bonazzi, M, Cossart, P

Microbes Infect. 2010
Participant Of
Event Information
Name Identifier Synonyms
listeriosis 11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
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