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CBL:GRB2 [cytosol]
Stable Identifier
R-HSA-182910
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
CBL binds InlB-activated MET (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
InlB:p-4Y-MET dimer:GRB2-1:CBL [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
InlB-activated MET phosphorylates CBL (Homo sapiens)
InlB:p-4Y-MET dimer:GRB2-1:CBL [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
CBL binds to GRB2 (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
Localization of CBL:GRB2 to the membrane (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
Signaling by MET (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
CBL binds MET (Homo sapiens)
CBL:GRB2,CBL [cytosol] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
MET phosphorylates CBL (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
Participants
components
CBL [cytosol]
(Homo sapiens)
GRB2-1 [cytosol]
(Homo sapiens)
Participates
as an input of
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CBL binds InlB-activated MET (Homo sapiens)
Localization of CBL:GRB2 to the membrane (Homo sapiens)
as a component of
InlB:p-4Y-MET dimer:GRB2-1:CBL [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
as a member of
CBL:GRB2,CBL [cytosol] (Homo sapiens)
as an output of
CBL binds to GRB2 (Homo sapiens)
Inferred To
CBL:GRB2 [cytosol]
(Bos taurus)
CBL:GRB2 [cytosol]
(Caenorhabditis elegans)
CBL:GRB2 [cytosol]
(Canis familiaris)
CBL:GRB2 [cytosol]
(Danio rerio)
CBL:GRB2 [cytosol]
(Drosophila melanogaster)
CBL:GRB2 [cytosol]
(Gallus gallus)
CBL:GRB2 [cytosol]
(Mus musculus)
CBL:GRB2 [cytosol]
(Rattus norvegicus)
CBL:GRB2 [cytosol]
(Sus scrofa)
CBL:GRB2 [cytosol]
(Xenopus tropicalis)
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